Clients with cardiovascular or peripheral vascular disorder must evaluate the possible pitfalls and Gains before initiating NRT. This cautious approach is warranted because of the likely adverse outcomes of NRT, such as greater coronary heart charge and hypertension, which could exacerbate preexisting cardiovascular disorders.

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In the situation of more mature adolescents, it is recommended to consider the utilization of NRT only if the likely Gains outweigh the possible hazards With this inhabitants.